Aging and the Dynorphinergic System: Evaluation of Memory and Motor Systems in Prodynorphin Knockout Mice

Effects of capsaicin in low doses and high doses on the small intestine motor response in wild-type and TRPV1 knockout mice

Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats.

The misuse of anabolic androgenic steroids has in several reports been associated with effects resulting in altered behavior. This study used the Morris water maze task to investigate the effect of high doses of the anabolic androgenic steroid nandrolone on spatial learning and memory in male rats. During the experiment, we observed a significantly impaired Morris water maze performance in the ...

H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice

Background:   H2-EB1 molecule which is the homolog of Human HLA-DRB1 is proposed to be associated with allergic rhinitis (AR). Construction of   H2-Eb1 knockout animal models provides a tool to elucidate the role of H2-EB1 and AR pathogenesis. Objective:   To establish the H2-Eb1 knockout model and investigate the H2-EB1 functions in   H2-Eb1 knockout mice as a model of AR. Methods: The Cre/Lox...

Spatial Memory, Motor Coordination, Cerebellar and Hippocampal Histoarchitectural Changes following Atropine Administration to Adult Mice

Atropine is a non-selective muscarinic receptor antagonist. In overdoses, atropine is poisonous. It is sometimes added to potentially addictive drugs, particularly anti-diarrhoea opioid drugs such as diphenoxylate or difenoxin. The aim of this study was to investigate spatial memory and motor changes associated with varying doses (5 and 10 mg/kg body weight) ingestion of atropine, as well as it...

Deletion of histidine decarboxylase (HDC) enhances the antinociceptive effects of orexin A in the central nervous system

It has long been established that histamine plays a role as a mediator of inflammation. From numerous studies, it has been well known that the amine has many pharmacological actions on a variety of organs. To evaluate the role of histamine in pain perception, we generated HDC knockout mice using a gene targeting method. Histamine is a hydrophilic autacoid, and in most tissues it is stored and s...